HGH Therapy and Sermorelin: What is the Difference?

Reviewed by Dr. Kenton Bruice, MD

As we age, our bodies naturally produce less human growth hormone (HGH), a hormone responsible for stimulating growth and cell reproduction. 

This decrease in HGH production can lead to a variety of age-related issues, including decreased muscle mass, increased body fat, and reduced energy levels.

In this blog post, we will do a deep dive into HGH. We will compare synthetic HGH therapy with human growth hormone peptides, specifically Sermorelin. We will explore their functions, benefits, side effects so that you can make an informed decision on which option is best for you.

Understanding Hormone Replacement Therapy (HRT)

Hormone replacement therapy works by supplementing your body’s natural hormone production with synthetic or bioidentical hormones. This therapy is often used to alleviate symptoms associated with aging, such as decreasing energy levels, decreased muscle mass, and difficulty losing weight.

Bioidentical hormone replacement therapy uses hormones derived from plant sources that have the same molecular structure as those naturally produced in the body. Synthetic hormone therapy, on the other hand, uses chemically created hormones.

Key Takeaway

HGH therapy directly supplements growth hormone levels in the body, but can suppress natural production and create a dependency. On the other hand, Sermorelin stimulates the pituitary gland to boost natural production of growth hormones, with minimal side effects and without suppressing natural hormone production.

What is Human Growth Hormone (HGH)?

HGH is a non-steroidal peptide hormone produced by the pituitary gland, responsible for promoting cellular growth and regeneration.

HGH helps our bodies in many ways:

  • Burns body fat and promotes weight loss.
  • Maintains, builds, and repairs healthy tissue in the brain and other organs.
  • Speeds up healing and promotes muscle tissue repair for faster recovery.
  • Reduces joint pain and improves mobility.
  • Builds lean muscle mass and helps lower cholesterol levels.
  • Enhances the quality and appearance of the skin.
  • Promotes hair growth.
  • Improves mental clarity and cognitive function.
  • Enhances the quality of sleep.
  • Increases athletic performance and boosts protein synthesis.
  • Benefits strength, sexual function, and bone growth.

When HGH levels are low, many of these functions can be negatively impacted, causing a decline in overall health and vitality.

What is Synthetic HGH Therapy?

Synthetic HGH therapy involves injecting synthetic human growth hormone into the body to increase HGH levels. This treatment is usually prescribed for individuals with medical conditions that affect their ability to produce HGH naturally or have been diagnosed with a growth hormone deficiency.

It is a highly effective treatment for increasing HGH levels and providing the benefits mentioned above. However, taking artificial HGH can suppress your natural production which can create a dependency on the artificial HGH.

What is Sermorelin?

Sermorelin is a human growth hormone peptide. It is a synthetic compound composed of 29 amino acids that works to stimulate the body’s natural production and secretion of HGH from the pituitary gland. Unlike synthetic HGH, Sermorelin does not replace your body’s natural HGH but instead works to enhance its production.

Sermorelin is usually administered through subcutaneous injections and has been clinically proven to increase HGH levels in the body. It is also considered a safer alternative to synthetic HGH therapy as it does not suppress natural hormone production and has minimal side effects.

The Benefits of Sermorelin

As mentioned, Sermorelin works by stimulating your body’s natural HGH production, which can provide numerous benefits for health and vitality. These benefits include:

  • Increased energy levels
  • Improved sleep quality
  • Enhanced cognitive function and mental clarity
  • Maintenance of lean muscle mass and increased muscle strength
  • Decreased body fat, leading to weight loss
  • Improved skin elasticity and appearance
  • Improved bone density and joint health

HGH Vs. Sermorelin

As discussed, the main difference between HGH and Sermorelin lies in their function. While HGH directly supplements growth hormone levels, Sermorelin stimulates the pituitary gland to boost the natural production of growth hormones.

Sermorelin is a safer option as it encourages the body to regulate the release of growth hormone and stimulates the pituitary gland to release more of its own growth hormone. This reduces the risk of dependency and potential side effects compared to HGH therapy.

Comparison Table Synthetic HGH vs Semorelin

AspectSynthetic HGHSermorelin
FunctionDirectly supplements growth hormones levels.Stimulates pituitary gland to boost natural production of growth hormones.
DeliveryAdministered through subcutaneous injections.Administered through subcutaneous injections or sublingual.
Side effectsCan suppress natural HGH production, which can create a dependency.Minimal side effects and does not suppress natural hormone production.
SafetyRisk of dependency and potential side effects.Safer option as it encourages the body to regulate the release of growth hormones.

Dr. Kenton Bruice: Your Hormone Doctor in Colorado

If you’ve been searching for ‘HGH peptide therapy near me’, you’ve come to the right place. Dr. Kenton Bruice, MD, specializes in HGH peptide therapy and has been serving the Denver and Aspen communities since 1998.

Dr. Bruice is dedicated to helping his patients achieve optimal health and vitality through personalized hormone replacement therapy plans.

Don’t let low HGH levels impact your quality of life. Book an appointment with Dr. Kenton Bruice to learn more about how HGH peptide therapy can benefit you.

To book an appointment at the Denver Hormone Institute of Colorado, call (303) 957-6686.

To book an appointment at the Aspen Hormone Institute of Colorado, call (970) 925-6655.


Are HGH peptides safe?

Yes, when administered under the supervision of a qualified healthcare professional, HGH peptides are safe and have minimal side effects.

Can you take semaglutide and sermorelin together?

Semorelin may interfere with blood glucose control and reduce the effectiveness of semaglutide and other diabetic medications. It is important to discuss your medical history and current medications with your doctor before beginning any kind of peptide therapy.

Does sermorelin increase estrogen?

Semorelin does not increase estrogen.

Does sermorelin increase testosterone?

Semorelin does not increase testosterone.

How long does it take for sermorelin to work?

The effects of sermorelin can vary from person to person, but most individuals start to feel the benefits within a few weeks of starting treatment. After 6 weeks, patients often see an improvement in energy, stamina and sleep. It typically takes 3 to 6 months to see maximum results.

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